Open studies / projects

INTERNATIONAL MULTI-INSTITUTIONAL RESEARCH BY TARPSWG

Check out the Studies that have been done and are currently recruiting for Collaborative Research:

FOR MORE INFORMATION ON ANY OF THESE STUDIES PLEASE CONTACT: tarpswg@gmail.com

Studies open to accrual

TARPSWG RETROSPECTIVE STUDIES

No Open Studies Currently

RESAR PROSPECTIVE STUDIES

No Open Studies Currently

Closed studies – in progress

TARPSWG RETROSPECTIVE STUDIES

TARPSWG – 2101

Retroperitoneal Lipoma: How rare are they? By the TARPSWG group

PI: William Tseng MD (University of Southern California, Los Angeles, US); Alessandro Gronchi (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy); Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US)

Co-I: Andre Oliveira, MD ; Judith Jebastin Thangaiah, MD (Mayo Clinic Rochester, US)

Status: Closed

Eligibility: Primary Retroperitoneal (RP) Lipomatous Tumors – including lipoma, WD liposarcoma, and angiomyolipoma. Our focus will ultimately be on RP lipomas. Minimum of 1 case required to enter the study

TARPSWG – 2102

The natural history of primary, extra-visceral, perivascular epitheloid cel tumours (PEComa) of the Retroperitoneum: The combined experience of the TARPSWG

PI: David Gyorki MD (Peter MacCallum Cancer Center, Melbourne, Australia)

Co-Is: Sameer Apte MD, Hayden Snow MD, Catherine Micthell MD (Peter MacCallum Cancer Center, Melbourne, Australia)

Status: Closed

Eligibility: Patients 18 years or older diagnosed with a primary, extra-visceral, retroperitoneal or abdominopelvic PEComa, or a tumour belonging to the family of PEComas over the past 10 years. Minimum of 1 case required to enter the study

TARPSWG – 2002

Inguinal Sarcomas – A Retrospective Analysis of Diagnosis, Clinical Features, Treatment Patterns and Outcomes (iSARC) – A study by TARPSWG

PI: Jeffrey Farma (Fox Chase Cancer Centre), Anthony Villano (Fox Chase Cancer Centre)

Co-I: Alessandro Gronchi (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy), Sinziana Dumitra MD (McGill University, Montreal, Canada)

Status: Closed

Eligibility: Any center can contribute to this study. All patients who have a primary soft tissue sarcoma originating from the spermatic cord between Jan 2005 and Dec 2021. Minimum of 1 case required to enter the study

TARPSWG-2009

The Natural History of Well-differentiated Liposarcoma in the Retroperitoneum: A TARPSWG Study

PIs: Mark Fairweather, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US); Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US)

Status: Closed, Currently Analyzing Data

TARPSWG-2001

The Evaluation and Outcome of Mesenteric and Intra-Abdominal Desmoids: A study by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

PIs: Carolyn Nessim, MD, MSc (The Ottawa Hospital, Ottawa, Canada) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Co-I: Kerianne Boulva, MD (The Ottawa Hospital, Ottawa, Canada)

Status: Closed, Data Clean Up

TARPSWG-1803

Retroperitoneal Myxoid LPS: Always a Metastasis? A study by the Trans-Atlantic Australasian RPS Working Group (TARPSWG).

PIs: Carolyn Nessim, MD, MSc (The Ottawa Hospital, Ottawa, Canada) ; Chandrajit, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US)

Co-I: Bibianna Purgina, MD (The Ottawa Hospital, Ottawa, Canada)

Status: Closed, Awaiting Material for MDM2 testing

TARPSWG-1805

STREXIT – “off trial” management and outcomes of primary non-metastatic RPS at centres that participated in the STRASS trial

PIs: Carol Swallow, MD, PhD (Mount Sinai Hospital, Princess Margaret Hospital, University of Toronto, Toronto, Canada) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy) ; Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US) ;Sylvie Bonvalot, MD (Institut Curie, PSL University, Paris, France)

Status: Closed, Manuscript in Progress

TARPSWG-1807

Pelvic Sarcomas – Retrospective Analysis of Clinical and Surgical Features and Outcomes (PELVISARC): A study by the Trans-Atlantic Australasian RPS Working Group (TARPSWG).

PIs: Marco Fiore, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy) ; Sinziana Dumitra, MD (MgGill University Health Center, Montreal, Canada)

Co-I: Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Status: Closed, Currently Analyzing Data

RESAR PROSPECTIVE STUDIES

TARPSWG – R1906

Benchmarks in RPS Surgery – A study by TARPSWG

PIs: Alessandro Gronchi MD, Marco Fiore MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy); Fabio Tirotta MD (University Hospital Birmingham NHS Foundation Trust, Birmingham, UK)

Status: Closed

Eligibility: Patients who underwent surgery for primary RPS at RESAR participating centers between January 2017 and June 2021. Minimum of 10 cases required to enter the study

TARPSWG-R2007

Response Evaluation after Neo-adjuvant Chemotherapy for Retroperitoneal Sarcoma

PIs: Winan vanHoudt MD (The Netherlands Cancer Institute, Amsterdam, Netherlands); Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Co-I: Sophie Rejjers MD (The Netherlands Cancer Institute, Amsterdam, Netherlands)

Status: Closed, Receiving Data from Centers

TARPSWG-R1901

Evaluating a Surgical Complexity Score to predict complications Post-Resection of a Retroperitoneal Sarcoma: A study by the Trans-Atlantic Australasian RPS Working Group (TARPSWG).

PI: Mark Fairweather, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US)

Co-I: Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US)

Status: Closed, Currently Analyzing Data

TARPSWG–R2005

Variations in patterns of care for retroperitoneal sarcoma: a study of the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group

PI: Hayden Snow, MD (Peter MacCallum Cancer Center, Melbourne, Australia

Co-I: David Gyorki, MD (Peter MacCallum Cancer Center, Melbourne, Australia

Status: Closed, Receiving Data from Centers

TARPSWG–R2006

Anticipated organs resection and pathologic infiltration – RESAntiPath

PIs: Marco Fiore, MD; Alessandro Gronchi (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Co-I: Dirk Strauss, MD (Royal Marsden Hospital, London, UK)

Status: Closed, Receiving Data from Centers

TARPSWG-R1905 (RESAR Project)

Accuracy and Concordance of Biopsy Diagnosis in Retroperitoneal Sarcoma (BISARC): An International Multi-Institutional Prospective Study by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

PIs: Sinziana Dumitra, MD (MgGill University Health Center, Montreal, Canada) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Co-I: Max Almond, MD (University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK)

Status: Closed, Receiving Data from Centers

Published papers

TARPSWG-2003

The Natural History of Ganglioneuroma: A Study by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

PI: Jason Sicklick, MD (Moores Cancer Center, University of California San Diego Health System, San Diego, US)

Co-Is: Sangkyu Noh, MS (Moores Cancer Center, University of California San Diego Health System, San Diego, US) ; Carolyn Nessim, MD, MSc, (The Ottawa Hospital, Ottawa, Canada)

Publication: https://pubmed.ncbi.nlm.nih.gov/35866666/

TARPSWG – 1904

An Analysis on Differentiation Changes and Outcomes at the Time of First Recurrence of Retroperitoneal Liposarcoma by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

PIs: Carolyn Nessim, MD, MSc (The Ottawa Hospital, Ottawa, Canada); Sanjay P Bagaria, MD, (Mayo Clinic, Jacksonville, US)

Co-Is: Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Publication: https://link.springer.com/article/10.1245%2Fs10434-021-10024-y

TARPSWG – CONSENSUS

Development of an Updated International Consensus on the Management of Primary Retroperitoneal Sarcoma (RPS) by TARPSWG

Publication: https://link.springer.com/article/10.1245%2Fs10434-021-09654-z

TARPSWG-1804

Primary Mesenteric Sarcomas – A Collaborative experience by the Trans-Atlantic Australasian RPS Working Group (TARPSWG).

PIs: Sam Ford, MD, PhD ; Hannah Tattersall, MD (University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK)

Co-I: Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Publication : https://pubmed.ncbi.nlm.nih.gov/33368277/

TARPSWG-1802

Postoperative pancreatic fistula following distal pancreatectomy for primary retroperitoneal sarcoma: an analysis by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

PIs: Sanjay Bagaria, MD (Mayo Clinic, Jacksonville, US) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Publication: https://link.springer.com/article/10.1245%2Fs10434-021-09739-9

TARPSWG-1801

Defining the Role of Neo-Adjuvant Systemic Therapy in High Risk Retroperitoneal Sarcoma: A Multi-Institutional TARPSWG Study

PIs: William Tseng MD (University of Southern California, Keck School of Medicine, LA, US ) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Publication: https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.11513

TARPSWG-1902

Postoperative Morbidity After Resection of Recurrent Retroperitoneal Sarcoma: A Report from the Trans-Atlantic Australasian RPS Working Group (TARPSWG).

PIs: Carolyn Nessim, MD, MSc (The Ottawa Hospital, Ottawa, Canada); Guy Lahat, MD, (Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel)

Co-Is: Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Publication: https://link.springer.com/article/10.1245%2Fs10434-020-09445-y

TARPSWG-2007

Virtual Biobanking for Retroperitoneal Sarcoma: A Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) Initiative

PIs: Rebecca Gladdy Md, PhD (University of Toronto); Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Publication: h ttps://link.springer.com/article/10.1245%2Fs10434-020-08775-1

TARPSWG-1903

Patterns of Recurrence and Survival Probability following Second Relapse of Retroperitoneal Sarcoma: A Study from TARPSWG

PIs: Winan vanHoudt, MD (The Netherlands Cancer Institute, Amsterdam Netherlands) ; Rebecca Gladdy, MD, PhD (Mount Sinai Hospital, Princess Margaret Hospital, University of Toronto, Toronto, Canada)

Co-I: Marco Fiore, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Italy)

Publication: https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/cncr.33139?af=R

TARPSWG-1700

Intercontinental Collaborative Experience with abdominal, retroperitoneal and pelvic schwannomas.

PIs: Sam Ford MD, PhD (University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Publication: https://bjssjournals.onlinelibrary.wiley.com/doi/abs/10.1002/bjs.11376

TARPSWG-1701

Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG

PIs: Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Publication:https://clincancerres.aacrjournals.org/content/25/8/2664.long

TARPSWG-1702

Pancreaticoduodenectomy in the surgical management of primary retroperitoneal sarcoma.

PIs: William Tseng MD (University of Southern California, Keck School of Medicine, LA, US ) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Publication:https://www.sciencedirect.com/science/article/pii/S0748798318301239

TARPSWG-1806

Identifying the Minimum Volume Threshold for Retroperitoneal Soft Tissue Sarcoma Resection: Merging National Data with Consensus Expert Opinion.

PIs: Waddah Al-Rafaie, MD (MedStar Georgetown University Hospital, Washington, DC)

Co-Is: Anthony M. Villano, MD, Alexander Zeymo, MS, Suzanne O’Neill, PhD, (MedStar Georgetown University Hospital, Washington, DC)

Publication: https://www.journalacs.org/article/S1072-7515(19)32116-7/abstract

TARPSWG

Variability in Patterns of Recurrence After Resection of Primary Retroperitoneal Sarcoma (RPS) A Report on 1007 Patients From the Multi-institutional Collaborative RPS Working Group

PIs: Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Co-Is: Carol Swallow (University of Toronto); Dirk Strauss (Royal Marsden); Sylvie Bonavalot (Institut Curie) et al.

Publication:https://tarpswg.files.wordpress.com/2017/04/08_variability-in-pattern-of-recurrence-tarpswg.pdf

TARPSWG

Post-relapse Outcomes After Primary Extended Resection of Retroperitoneal Sarcoma: A Report From the Trans-Atlantic RPS Working Group

PIs: Carol Swallow (University of Toronto); Andrea MacNeill (Vancouver)

Co-Is: Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy); Dirk Strauss (Royal Marsden); Sylvie Bonavalot (Institut Curie) et al.

Publication:https://tarpswg.files.wordpress.com/2017/04/post-relapse-outcome-rps_cancer-2017.pdf

TARPSWG

Postoperative Morbidity After Radical Resection of Primary Retroperitoneal Sarcoma A Report From the Transatlantic RPS Working Group

PIs: Dirk Strauss (Royal Marsden); Andrea MacNeill (Vancouver)

Co-Is: Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US) ; Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy); Sylvie Bonavalot (Institut Curie); Carol Swallow (Unvisersity of Toronto) et al.
Publication:https://tarpswg.files.wordpress.com/2017/05/morbidity-tarpswg.pdf

TARPSWG

Radiotherapy for retroperitoneal liposarcoma: A report from the Transatlantic Retroperitoneal Sarcoma Working Group

PIs: Rick Hass (The Netherlands Cancer Institute); Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Co-Is: Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US) ; Sylvie Bonavalot (Institut Curie); Carol Swallow (Unvisersity of Toronto); Piotr Rutkowski (Maria Sklodowska‐Curie Institute–Oncology Center) et al.

Publication:https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.31927

TARPSWG

External validation of a multi-institutional retroperitoneal sarcoma nomogram

PIs: Chandrajit Raut, MD (Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, US); Alessandro Gronchi, MD (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy)

Co-Is: Sylvie Bonavalot (Institut Curie); Carol Swallow (Unvisersity of Toronto); Piotr Rutkowski (Maria Sklodowska‐Curie Institute–Oncology Center); Peter Hohenberger (Mannheim University); Dirk Strauss (Royal Marsden) et al.

Publication:https://acsjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/cncr.29931

TARPSWG – CONSENSUS

Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult: A Consensus Approach From the Trans-Atlantic RPS Working Group

Publication:https://tarpswg.files.wordpress.com/2017/03/rps_2015_management-of-primary-retroperitoneal-sarcoma_transatlantic-working-group_aso.pdf

TARPSWG – CONSENSUS

Management of Recurrent Retroperitoneal Sarcoma (RPS) in the Adult: A Consensus Approach from the Trans-Atlantic RPS Working Group

Publication:https://tarpswg.files.wordpress.com/2017/04/management-of-recurrent-rps_tarpswg-2.pdf

TARPSWG – CONSENSUS

Management of metastatic retroperitoneal sarcoma: a consensus approach from the Trans-Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG)

Publication:https://www.journals.elsevier.com/annals-of-oncology