In this series from TARPSWG the authors examined longitudinal outcomes of patients with a second recurrence of RPS after complete resection of a first local recurrence. They found that patients who were eligible for radical surgical resection of a second LR were found to have a relatively robust median OS of 59 months, despite the recurrent nature of the disease. In contrast, the median OS of patients who did not undergo surgery was only 18 months. Patients who develop both DM and LR have a dismal prognosis, and therefore the role of surgery in this group is likely limited to palliative intervention.

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